Transcribed Image Text: An extra piece. In one type of mutation leading to a form of thalassemia, the mutation of a single base (G to
Transcribed Image Text: An extra piece. In one type of mutation leading to a form of
thalassemia, the mutation of a single base (G to A) generates a new 3′
3′ splice site (blue in the illustration below) akin to the normal one
(yellow) but farther upstream.
Normal 3′ end
5′ CCTATTGGTCTATTITCCACCCITAGGCTGCTG 3′
5′ CCTATTAGTCTAIIIICCACCCTTAGGCTGCTG 3′
is the amino acid sequence of the extra segment of protein
synthesized in a thalassemic patient having a mutation leading to
aberrant splicing? The reading frame after the splice site begins with
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