: Mark Cunamad 11. A 40-year-old woman with rheumatoid art comes to the physician because of a 1-month history of episodes of nausea, headaches, twique,

: Mark Cunamad 11. A 40-year-old woman with rheumatoid art comes to the physician because of a 1-month history of episodes of nausea, headaches, twique, and mouth oresh ana days whe treatment with methotrexate (10 mg once weekly). Physical examination shows loss sweling and converness of the joints than the previous visit 2 months ago Laboratory Mudes show macrocytic erythrocytes. Which of the following modifications to this patient’s medication regimen is most appropriate to decrease the adverse effects of methotrexate? A) Addition of leucovori B) Administration of 5 mg of methotrexate twice weekly c) Administration of vitamin B (pyridoxine) 24 hours after methotrexate Dj Daily administration of ranitidine and acetaminophen E) Initiation of misoprostol therapy